[BLAST MODEL CALCULATOR]

About This Calculator

This online risk calculator implements three prognostic models for Chronic Myelomonocytic Leukemia (CMML), developed by Tefferi et al. (Blood, 2025). Use it to estimate overall survival and blast transformation risk in CMML patients.

BLAST (Peripheral Blood Blast, Leukocytosis, and Anemia-based risk Stratification Tool) predicts Chronic Myelomonocytic Leukemia prognosis using three clinical variables: circulating blasts ≥2%, leukocyte count ≥13 × 10⁹/L, and gender-specific anemia severity. No molecular testing required.

BLAST-mol enhances CMML survival prediction with molecular data, classifying patients into Low (LMR), Intermediate (IMR), or High (HMR) molecular risk tiers based on favorable mutations (TET2, PHF6) and unfavorable mutations (DNMT3A, U2AF1, BCOR, SETBP1, PTPN11, NRAS, RUNX1, TP53, ASXL1) or adverse karyotype.

BT Risk predicts cumulative incidence of blast transformation to Acute Myeloid Leukemia (AML) at 24 months using PHF6 mutation status, DNMT3A, ASXL1, bone marrow blasts, circulating blasts, and leukocyte count.

Together, these CMML risk calculators help clinicians stratify patients into Low, Intermediate, and High risk categories to guide allogeneic stem cell transplantation (ASCT) timing and treatment decisions.